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HIPGEN COMMUNICATION ACTIVITIES

PROJECT VIDEO

HIPGEN study

What previous work is the HIPGEN project based on

What are the goals of the HIPGEN project

How the HIPGEN project is going to improve patients quality of life

PROJECT LEAFLET

HIPGEN leaflet - February 2019 version

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IOF NEWSLETTER

March 30, 2020 - Report on the Second Annual HIPGEN Meeting in Berlin

July 15, 2019 - Interview with Professor Tobias Winkler, Hipgen project coordinator

March 14, 2019 - First Annual HIPGEN Meeting reviews current progress and challenges



PUBLIC RELATIONS

June 26, 2019 - "Long Night of Sciences", Berlin, Germany

June 15, 2019 - "Long Night of Sciences", Berlin, Germany


HIPGEN SCIENTIFIC ARTICLES & POSTERS

Qazi TH, Duda GN, Ort MJ, Perka C, Geissler S*, Winkler T* (*shared senior).  Cell therapy to improve regeneration of skeletal muscle injuries. J Cachexia Sarcopenia Muscle 2019, 10, 501-516.

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Moll G, Ankrum JA, Kamhieh-Milz J, Bieback K, Ringdén O, Volk HD, Geissler S*, Reinke P* (*shared senior). Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines. Trends Mol Med 2019, 25, 149-163.

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Klein O, Strohschein K, Nebrich G, Fuchs M, Thiele H, Giavalisco P, Duda GN, Winkler T, Kobarg JH, Trede D, Geissler S. Unraveling local tissue changes within severely injured skeletal muscles in response to MSC-based intervention using MALDI Imaging mass spectrometry. Scientific Reports 2018, 8, art.12677.

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Antonietta Silini, Alice Masserdotti, Andrea Papait, Ornella Parolini. Shaping the Future of Perinatal Cells: Lessons From the Past and Interpretations of the Present. Frontiers in Bioengineering and Biotechnology; Tissue Engineering and Regenerative Medicine: Future and Sustainability 2019, 7, art 75.

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Tobias Winkler, Carsten Perka, Philipp von Roth, Alison N. Agres, Henning Plage, Bernd Preininger, Matthias Pumberger, Sven Geissler , Esther Lukasiewicz Hagai, Racheli Ofir, Lena Pinzur, Eli Eyal, Gisela Stoltenburg Didinger, Christian Meisel, Christine Consentius, Mathias Streitz, Petra Reinke, Georg N. Duda*& Hans-Dieter Volk. Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty.  J Cachexia Sarcopenia Muscle 2018, 9, 880-897.

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Andrea Papait, Elsa Vertua, Marta Magatti , Sabrina Ceccariglia, Silvia De Munari, Antonietta Rosa Silini , Michal Sheleg, Racheli Ofir and Ornella Parolini. Mesenchymal Stromal Cells from Fetal and Maternal Placenta Possess Key Similarities and Differences: Potential Implications for Their Applications in Regenerative Medicine. Cells 2020, 9, 127.

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GISM Annual Meeting, 4-5 April 2019, Genova Poster presentation
In vitro immunomodulatory comparison of Maternal vs Fetal Placenta-derived cells
Andrea Papait, Marta Magatti, Elsa Vertua, Antonietta Silini, Racheli Ofir, Ornella Parolini

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Magatti M, Stefani FR, Papait A, Cargnoni A, Masserdotti A, Silini A.R., Parolini O. Perinatal Mesenchymal Stromal Cells and Their Possible Contribution to Fetal-Maternal Tolerance. Cells 2019, 8 (11), 1401.

open access


Moll G, Drzeniek N, Kamhieh-Milz J, Geissler S, Volk HD, Reinke P. MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy. Front Immunol 2020 Volume 11 Article 1091.

open access


Eder C, Schmidt-Bleek K, Geissler S, Sass FA, Maleitzke T, Pumberger M, Perka C, Duda GN, Winkler T. Mesenchymal stromal cell and bone marrow concentrate therapies for musculoskeletal indications: a concise review of current literature. Molecular Biology Reports 2020 47, 4789-4814.

open access


Schoon J, Ort MJ, Huesker K, Geissler S, Rakow A. Diagnosis of Metal Hypersensitivity in Total Knee Arthroplasty: A Case Report. Front Immunol. 2019 Volume 10 Article 2758.

open access


Sadeghi B, Moretti G, Arnberg F, Samén E, Kohein B, Catar R, Kamhieh-Milz J, Geissler S, Moll G, Holmin S, Ringdén O. Preclinical Toxicity Evaluation of Clinical Grade Placenta-Derived Decidua Stromal Cells. Front Immunol. 2019 Volume 10, Article 2685.

open access


Andrzejewska A, Catar R, Schoon J, Qazi TH, Sass FA, Jacobi D, Blankenstein A, Reinke S, Krüger D, Streitz M, Schlickeiser S, Richter S, Souidi N, Beez C, Kamhieh-Milz J, Krüger U, Zemojtel T, Jürchott K, Strunk D, Reinke P, Duda G, Moll G, Geissler S. Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional. Front Immunol. 2019 Volume 10, Article 2474.

open access


Ort MJ, Geissler S, Rakow A, Schoon J. The Allergic Bone Marrow? The Immuno-Capacity of the Human Bone Marrow in Context of Metal-Associated Hypersensitivity Reactions. Front Immunol. 2019 Volume 10, Article 2232.

open access


Qazi TH, Mooney DJ, Duda GN, Geissler S. Niche-mimicking interactions in peptide-functionalized 3D hydrogels amplify mesenchymal stromal cell paracrine effects. Biomaterials Biomaterials 2020, 230, 119639.

open access


Qazi TH, Tytgat L, Dubruel P, Duda GN, Van Vlierberghe S, Geissler S. Extrusion Printed Scaffolds with Varying Pore Size As Modulators of MSC Angiogenic Paracrine Effects. ACS Biomater Sci Eng. 2019, 5, 10, 5348-5358.

open access


Moll G, Drzeniek N, Kamhieh-Milz J, Geissler S, Reinke P. Editorial comment: variables affecting the presence of mesenchymal stromal cells in the peripheral blood and their relationship with apheresis product. Br J Haematol. 2020, 189 593-596.

open access


Xiang G, Lippens E, Hafeez S, Duda GN, Geissler S, Qazi TH. Oxidized alginate beads for tunable release of osteogenically potent mesenchymal stromal cells. Mater Sci Eng C Mater Biol Appl. 2019.

open access


Sónia A. Alves, Rainald M. Ehrig, Peter C. Raffalt, Alwina Bender, Georg N. Duda and Alison N. Agres. Quantifying Asymmetry in Gait: The Weighted Universal Symmetry Index to Evaluate 3D Ground Reaction Forces. Frontiers in Bioengineering and Biotechnology: Biomechanics section. 2020, Volume 8, Article 579511.

open access


HIPGEN CONFERENCES

 

Type Researcher(s) involved Event (Title, location, dates) Activity title
(e.g. title of poster or talk, etc.)
Type of audience Estimated persons reached
Participation to a conference P1-CHARITE (Christian Eder) Certified clinic conference traumatology, Berlin, German, 06.03.2019 Presentation "Studieninformation im Rahmen der Klinikkonferenz CMSC/CVK" Scientific Community (Higher Education, Research) 25
Participation to a conference P1-CHARITE (Sven Geißler) Annual meeting of the Interdisciplinary Group for Laboratory and Flow Cytometry, Frankfurt/Main, German, 07.-09.03.2019 Keynote lecture "MSC-mediated muscle regeneration" cientific Community (Higher Education, Research) 250
Participation to a conference P1-CHARITE (Sven Geißler & Taimoor Qazi) TERMIS World Congress 2018, Kyoto, Japan, 04.07.2019 Talk "Mimicking N-cadherin Interactions via Engineered Hydrogels Confers Growth Factor Sensitivity and Enhances Paracrine Activity of Mesenchymal Stromal Cells" Scientific Community (Higher Education, Research) 600
Participation to a conference P1-CHARITE (Sven Geißler & Taimoor Qazi) TERMIS World Congress 2018, Kyoto, Japan, 04.07.2019 Talk "MSCs delivered using structurally optimized hydrogels enhance skeletal muscle regeneration by paracrine mechanism" Scientific Community (Higher Education, Research) 600
Participation to a conference P1-CHARITE (Sven Geißler & Taimoor Qazi) TERMIS World Congress 2018, Kyoto, Japan, 04.07.2019 Talk "Mesenchymal Stromal Cells Improve Regeneration of Severely Injured Muscles via Local Modulation of CD4+ and CD8+ T Cell Levels" Scientific Community (Higher Education, Research) 600
Participation to a conference P1-CHARITE (Sven Geißler) Forum Companion-Dx: Biomarker Trends & Perspectives for the Personalized medicine, Berlin, Germany, 21.06.2019 Talk "Personalized medicine in patients with healing disorders" Industry 300
Participation to a conference P1-CHARITE (Sven Geißler & Taimoor Qazi) TERMIS World Congress 2018, Kyoto, Japan, 04.07.2019 Talk "Mimicking N-cadherin Interactions via Engineered Hydrogels Confers Growth Factor Sensitivity and Enhances Paracrine Activity of Mesenchymal Stromal Cells" Scientific Community (Higher Education, Research) 600
Participation to a conference P1-CHARITE (Sven Geißler & Taimoor Qazi) TERMIS World Congress 2018, Kyoto, Japan, 04.07.2019 Talk "MSCs delivered using structurally optimized hydrogels enhance skeletal muscle regeneration by paracrine mechanism" Scientific Community (Higher Education, Research) 600
Participation to a conference P1-CHARITE (Sven Geißler & Taimoor Qazi) TERMIS World Congress 2018, Kyoto, Japan, 04.07.2019 Talk "Mesenchymal Stromal Cells Improve Regeneration of Severely Injured Muscles via Local Modulation of CD4+ and CD8+ T Cell Levels" Scientific Community (Higher Education, Research) 600
Participation to a conference / Poster P1-CHARITE WCO IOF-ESCEO, VIRTUAL CONGRESS - WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES; August 20-22, 2020 Poster P1127 - PLACENTAL CELL THERAPY FOR THE TREATMENT OF MUSCLE TRAUMA AND POSTOPERATIVE STRESS IN HIP FRACTURE PATIENTS: FROM PRECLINICAL MODELS TO CLINICAL PHASE III. T. Winkler, S. Geisler, A. Agres, C. Eder, T. Maleitzke, R. Ofir, P. Reinke, C. Perka, H. D. Volk, G. N. Duda Scientific Community (Higher Education, Research) 500
Participation to a conference P1-Charite ( Georg Duda) Annual Retreat of the BIH Center for Regenerative Therapies (BCRT), Radisson Blu Hotel Berlin, 28 - 29 September 2020 Talk "Presentation of research fields to the ESC – Musculoskeletal Regeneration" Scientific Community (Higher Education, Research) 90
Participation to a conference P3-OUH (Hagen Schmal) HIPGEN – stem cells for sarcopenia treatment – Status of the RCTDen Ortopædkirurgiske Forskningsenhed 26. 02.2018 Talk Scientific Community (Higher Education, Research) 20
Organisation of a workshop P3-OUH Labmeeting 26.02. 2019, Odense Talk Scientific Community (Higher Education, Research) 20
Participation to a conference P4-CREM: Ornella Parolini, Andrea Papait (presenting author), Marta Magatti, Elsa Vertua, Antonietta Silini; PLURISTEM: Racheli Ofir National Conference: Gruppo Italiano Staminali Mesenchimali (GISM, Italian Mesenchymal Stem Cell Group) 2019 Annual Meeting, "Research Challenges for Clinical Applications of MSCs", Genoa, Italy, April 4-5, 2019 In vitro immunomodulatory comparison of Maternal vs Fetal Placenta-derived cells Scientific Community (Higher Education, Research) 150
Participation to a conference P4-CREM Andrea Papait (presenting author), Elsa Vertua, Silvia De Munari, Marta Magatti, Antonietta Silini, Racheli Ofir, Ornella Parolini 5th International Conference by International Fetal Immunology and Transplantation Society (iFeTIS), Singapore, September 6-7, 2019 Oral presentation "Comparison of the immunological properties of MSC-like cells from fetal and maternal placenta" Scientific Community (Higher Education, Research) 100
Organisation of a Conference P8-IOF WCO-IOF-ESCEO, Paris, April 4-7 Flyer available at IOF booth Scientific Community (Higher Education, Research) 4000+

HIPGEN PRESS RELEASES & MAGAZINE ARTICLES

Israel, August 8, 2018 - Pluristem
Pluristem Initiates Two Pivotal Phase III Studies in Israel

Italy, April, 2019 - PLATINUM
La Placenta, fonte di cellule

Indiana, October 17, 2018 - NewScientist - NEWS & TECHNOLOGY
Human placenta stem cells help people recover from hip surgery

Indiana, Sptember 23, 2018 - IMRC
IRMC patient receives historic stem cell surgery

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HAIFA, Israel, April 25, 2018 - Pluristem Therapeutics Inc
U.S. Food and Drug Administration (FDA) has cleared Pluristem’s Investigational Drug Application (IND) of its PLX-PAD cell therapy for HIPGEN study

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