PROJECT VIDEO
HIPGEN study
What previous work is the HIPGEN project based on
What are the goals of the HIPGEN project
How the HIPGEN project is going to improve patients quality of life
PROJECT LEAFLET
HIPGEN leaflet - February 2019 version
IOF NEWSLETTER
December 27, 2021 - Important milestone for HIPGEN as it reaches enrolment target
March 30, 2021 - HIPGEN Third annual meeting (virtual)
March 30, 2020 - Report on the Second Annual HIPGEN Meeting in Berlin
October 28, 2019 - HIPGEN presented at RegMed Forum 2019 in Berlin
July 15, 2019 - Interview with Professor Tobias Winkler, Hipgen project coordinator
March 14, 2019 - First Annual HIPGEN Meeting reviews current progress and challenges
PUBLIC RELATIONS
June 26, 2019 - "Long Night of Sciences", Berlin, Germany
June 15, 2019 - "Long Night of Sciences", Berlin, Germany
Qazi TH, Duda GN, Ort MJ, Perka C, Geissler S*, Winkler T* (*shared senior). Cell therapy to improve regeneration of skeletal muscle injuries. J Cachexia Sarcopenia Muscle 2019, 10, 501-516.
Moll G, Ankrum JA, Kamhieh-Milz J, Bieback K, Ringdén O, Volk HD, Geissler S*, Reinke P* (*shared senior). Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines. Trends Mol Med 2019, 25, 149-163.
Klein O, Strohschein K, Nebrich G, Fuchs M, Thiele H, Giavalisco P, Duda GN, Winkler T, Kobarg JH, Trede D, Geissler S. Unraveling local tissue changes within severely injured skeletal muscles in response to MSC-based intervention using MALDI Imaging mass spectrometry. Scientific Reports 2018, 8, art.12677.
Antonietta Silini, Alice Masserdotti, Andrea Papait, Ornella Parolini. Shaping the Future of Perinatal Cells: Lessons From the Past and Interpretations of the Present. Frontiers in Bioengineering and Biotechnology; Tissue Engineering and Regenerative Medicine: Future and Sustainability 2019, 7, art 75.
Tobias Winkler, Carsten Perka, Philipp von Roth, Alison N. Agres, Henning Plage, Bernd Preininger, Matthias Pumberger, Sven Geissler , Esther Lukasiewicz Hagai, Racheli Ofir, Lena Pinzur, Eli Eyal, Gisela Stoltenburg Didinger, Christian Meisel, Christine Consentius, Mathias Streitz, Petra Reinke, Georg N. Duda*& Hans-Dieter Volk. Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty. J Cachexia Sarcopenia Muscle 2018, 9, 880-897.
Andrea Papait, Elsa Vertua, Marta Magatti , Sabrina Ceccariglia, Silvia De Munari, Antonietta Rosa Silini , Michal Sheleg, Racheli Ofir and Ornella Parolini. Mesenchymal Stromal Cells from Fetal and Maternal Placenta Possess Key Similarities and Differences: Potential Implications for Their Applications in Regenerative Medicine. Cells 2020, 9, 127.
GISM Annual Meeting, 4-5 April 2019, Genova Poster presentation
In vitro immunomodulatory comparison of Maternal vs Fetal Placenta-derived cells
Andrea Papait, Marta Magatti, Elsa Vertua, Antonietta Silini, Racheli Ofir, Ornella Parolini
Magatti M, Stefani FR, Papait A, Cargnoni A, Masserdotti A, Silini A.R., Parolini O. Perinatal Mesenchymal Stromal Cells and Their Possible Contribution to Fetal-Maternal Tolerance. Cells 2019, 8 (11), 1401.
Moll G, Drzeniek N, Kamhieh-Milz J, Geissler S, Volk HD, Reinke P. MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy. Front Immunol 2020 Volume 11 Article 1091.
Eder C, Schmidt-Bleek K, Geissler S, Sass FA, Maleitzke T, Pumberger M, Perka C, Duda GN, Winkler T. Mesenchymal stromal cell and bone marrow concentrate therapies for musculoskeletal indications: a concise review of current literature. Molecular Biology Reports 2020 47, 4789-4814.
Schoon J, Ort MJ, Huesker K, Geissler S, Rakow A. Diagnosis of Metal Hypersensitivity in Total Knee Arthroplasty: A Case Report. Front Immunol. 2019 Volume 10 Article 2758.
Sadeghi B, Moretti G, Arnberg F, Samén E, Kohein B, Catar R, Kamhieh-Milz J, Geissler S, Moll G, Holmin S, Ringdén O. Preclinical Toxicity Evaluation of Clinical Grade Placenta-Derived Decidua Stromal Cells. Front Immunol. 2019 Volume 10, Article 2685.
Andrzejewska A, Catar R, Schoon J, Qazi TH, Sass FA, Jacobi D, Blankenstein A, Reinke S, Krüger D, Streitz M, Schlickeiser S, Richter S, Souidi N, Beez C, Kamhieh-Milz J, Krüger U, Zemojtel T, Jürchott K, Strunk D, Reinke P, Duda G, Moll G, Geissler S. Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional. Front Immunol. 2019 Volume 10, Article 2474.
Ort MJ, Geissler S, Rakow A, Schoon J. The Allergic Bone Marrow? The Immuno-Capacity of the Human Bone Marrow in Context of Metal-Associated Hypersensitivity Reactions. Front Immunol. 2019 Volume 10, Article 2232.
Qazi TH, Mooney DJ, Duda GN, Geissler S. Niche-mimicking interactions in peptide-functionalized 3D hydrogels amplify mesenchymal stromal cell paracrine effects. Biomaterials Biomaterials 2020, 230, 119639.
Qazi TH, Tytgat L, Dubruel P, Duda GN, Van Vlierberghe S, Geissler S. Extrusion Printed Scaffolds with Varying Pore Size As Modulators of MSC Angiogenic Paracrine Effects. ACS Biomater Sci Eng. 2019, 5, 10, 5348-5358.
Moll G, Drzeniek N, Kamhieh-Milz J, Geissler S, Reinke P. Editorial comment: variables affecting the presence of mesenchymal stromal cells in the peripheral blood and their relationship with apheresis product. Br J Haematol. 2020, 189 593-596.
Xiang G, Lippens E, Hafeez S, Duda GN, Geissler S, Qazi TH. Oxidized alginate beads for tunable release of osteogenically potent mesenchymal stromal cells. Mater Sci Eng C Mater Biol Appl. 2019.
Sónia A. Alves, Rainald M. Ehrig, Peter C. Raffalt, Alwina Bender, Georg N. Duda and Alison N. Agres. Quantifying Asymmetry in Gait: The Weighted Universal Symmetry Index to Evaluate 3D Ground Reaction Forces. Frontiers in Bioengineering and Biotechnology: Biomechanics section. 2020, Volume 8, Article 579511.
Drzeniek NM, Mazzocchi A, Schlickeiser S, Forsythe SD, Moll G, Geißler S, Reinke P, Gossen M, Gorantla VS, Volk HD, Soker S. Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells. Biofabrication 2021.
T. Winkler, M. L. Costa, R. Ofir, O. Parolini, S. Geissler, H-D. Volk, C. Eder, On behalf of the HIPGEN Author Consortium. HIPGEN - A randomized, multicenter phase III study using intramuscular PLacenta-eXpanded stromal cells (PLX-PAD) therapy for recovery following hip fracture arthroplasty: study design. Bone and Joint Open. 2022, 3-4:340–347.
Rusan Catar, Guido Moll, Isa Hosp, Michel Simon, Christian Luecht, Hongfan Zhao, Dashan Wu, Lei Chen, Julian Kamhieh-Milz, Katarzyna Korybalska, Daniel Zickler, Janusz Witowski. Transcriptional Regulation of Thrombin-Induced Endothelial VEGF Induction and Proangiogenic Response. Cells. 2021.
Gady Goldsobel, Christoph von Herrath, Stephan Schlickeiser, Nicola Brindle, Frauke Stähler, Petra Reinke, Zami Aberman, Racheli Ofir, Gabriella Dessole, Stefano Benvenuti, Nuno M. Neves, Rui L. Reis, Guido Moll, and Hans-Dieter Volk. RESTORE Survey on the Public Perception of Advanced Therapies and ATMPs in Europe. Why the European Union Should Invest More! Frontiers in Medicine 2021.
Rusan Catar and Guido Moll et al. Expanded Hemodialysis Therapy Ameliorates Uremia-Induced Systemic Microinflammation and Endothelial Dysfunction by Modulating VEGF, TNF-α and AP-1 Signaling. Frontiers in Immunology 2022.
Olle Ringden, Guido Moll, Britt Gustavsson, Behnam Sadeghi. Mesenchymal Stromal Cells for Enhancing Hematopoietic Engraftment and Treatment of Graft-versus-Host Disease, Hemorrhages and Acute Respiratory Distress Syndrome. Frontiers in Immunology 2022.
Guido Moll, James A. Ankrum, Scott D. Olson, Jan A. Nolta. Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products. Stem Cells Translational Medicine 2022, XX, 1-12.
Jayeeta Giri and Guido Moll. MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel. Current Stem Cell Reports 2022.
Andrea Papait, Antonietta Silini, Maria Gazouli, Ricardo Malvicini, Maurizio Muraca, Lorraine O’Driscoll, Natalia Pacienza, Wei Seong Toh, Gustavo Yannarelli, Peter Ponsaerts, Ornella Parolini, Günther Eissner, Michela Pozzobon, Sai Kiang Lim and Bernd Giebel. Perinatal derivatives: How to best validate their immunomodulatory functions. Front Bioeng Biotechnol 2022, 981061.
Sónia A. Alves, Marco Preuße, Hagen Hommel, Georg N. Duda, Alison N. Agres. The Recovery of Weight-Bearing Symmetry After Total Hip Arthroplasty Is Activity-Dependent Front Bioeng Biotechnol. Sec Biomechanics 2022, 813345.
Sónia A. Alves, Jörg Polzehl, Nicholas M. Brisson, alwina Bender, Alison N. Agres, Philipp Damm, Georg N. Duda. Ground reaction forces and external hip joint moments predict in vivo hip contact forces during gait. Journal of Biomechanics 2022, 111037.
Gabriele Brachtl, Rodolphe Poupardin, Sarah Hochmann, Anna Raninge, Karsten Jürchott, Mathias Streitz, Stephan Schlickeiser, Michaela Oeller, Martin Wolf, Katharina Schallmoser, Hans-Dieter Volk, Sven Geissler and Dirk Strunk. Batch Effects during Human Bone Marrow Stromal Cell Propagation Prevail Donor Variation and Culture Duration: Impact on Genotype, Phenotype and Function. Cells 2022.
Benedikt Leinauer, […], Sven Geißler,[…], Gernot Jundt. H3F3A-mutated giant cell tumour of bone without giant cells—clinical presentation, radiology and histology of three cases. Histopathology 2022.
Guido Moll , James A. Ankrum, Scott D. Olson, Jan A. Nolta. Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products. Stem Cells Translational Medicine 2022.
Chasen Cottle, Amanda Paige Porter, Ariel Lipat, Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai. Mesenchymal Stem/Stromal Cells as a Therapeutic Tool in Cell-Based Therapy and Regenerative Medicine: An Introduction Expertise to the Topical Collection. Cells 2022.
Chasen Cottle, Amanda Paige Porter, Ariel Lipat, Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai. Impact of Cryopreservation and Freeze‑Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics. Current Stem Cell Reports 2022.
Vivian Capilla-González, Vicente Herranz-Pérez, Rachel Sarabia-Estrada, Nadir Kadri and Guido Moll. Editorial: Mesenchymal Stromal Cell Therapy for Regenerative Medicine Front. Cell. Neurosci. 2022.
Guido Moll, Frances Verter. Therapeutic MSC Infusions: When more of a good thing is not always better. To learn more about cord blood banking, visit Parent's Guide to Cord Blood Foundation. Parents guide cordblood 2022.
| Type | Researcher(s) involved | Event (Title, location, dates) | Activity title (e.g. title of poster or talk, etc.) |
Type of audience | Estimated persons reached |
|---|---|---|---|---|---|
| Participation to a conference | P1 - CHARITE (Christian Eder) | Certified clinic conference traumatology, Berlin, German, 06.03.2019 | Presentation "Studieninformation im Rahmen der Klinikkonferenz CMSC/CVK" | Scientific Community (Higher Education, Research) | 25 |
| Participation to a conference | P1 - CHARITE (Sven Geißler) | Annual meeting of the Interdisciplinary Group for Laboratory and Flow Cytometry, Frankfurt/Main, German, 07.-09.03.2019 | Keynote lecture "MSC-mediated muscle regeneration" | cientific Community (Higher Education, Research) | 250 |
| Participation to a conference | P1 - CHARITE (Sven Geißler & Taimoor Qazi) | TERMIS World Congress 2018, Kyoto, Japan, 04.07.2019 | Talk "Mimicking N-cadherin Interactions via Engineered Hydrogels Confers Growth Factor Sensitivity and Enhances Paracrine Activity of Mesenchymal Stromal Cells" | Scientific Community (Higher Education, Research) | 600 |
| Participation to a conference | P1 - CHARITE (Sven Geißler & Taimoor Qazi) | TERMIS World Congress 2018, Kyoto, Japan, 04.07.2019 | Talk "MSCs delivered using structurally optimized hydrogels enhance skeletal muscle regeneration by paracrine mechanism" | Scientific Community (Higher Education, Research) | 600 |
| Participation to a conference | P1 - CHARITE (Sven Geißler & Taimoor Qazi) | TERMIS World Congress 2018, Kyoto, Japan, 04.07.2019 | Talk "Mesenchymal Stromal Cells Improve Regeneration of Severely Injured Muscles via Local Modulation of CD4+ and CD8+ T Cell Levels" | Scientific Community (Higher Education, Research) | 600 |
| Participation to a conference | P1 - CHARITE (Sven Geißler) | Forum Companion-Dx: Biomarker Trends & Perspectives for the Personalized medicine, Berlin, Germany, 21.06.2019 | Talk "Personalized medicine in patients with healing disorders" | Industry | 300 |
| Participation to a conference | P1 - CHARITE (Sven Geißler & Taimoor Qazi) | TERMIS World Congress 2018, Kyoto, Japan, 04.07.2019 | Talk "Mimicking N-cadherin Interactions via Engineered Hydrogels Confers Growth Factor Sensitivity and Enhances Paracrine Activity of Mesenchymal Stromal Cells" | Scientific Community (Higher Education, Research) | 600 |
| Participation to a conference | P1 - CHARITE (Sven Geißler & Taimoor Qazi) | TERMIS World Congress 2018, Kyoto, Japan, 04.07.2019 | Talk "MSCs delivered using structurally optimized hydrogels enhance skeletal muscle regeneration by paracrine mechanism" | Scientific Community (Higher Education, Research) | 600 |
| Participation to a conference | P1 - CHARITE (Sven Geißler & Taimoor Qazi) | TERMIS World Congress 2018, Kyoto, Japan, 04.07.2019 | Talk "Mesenchymal Stromal Cells Improve Regeneration of Severely Injured Muscles via Local Modulation of CD4+ and CD8+ T Cell Levels" | Scientific Community (Higher Education, Research) | 600 |
| Participation to a conference / Poster | P1 - CHARITE | WCO IOF-ESCEO, VIRTUAL CONGRESS - WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES; August 20-22, 2020 | Poster P1127 - PLACENTAL CELL THERAPY FOR THE TREATMENT OF MUSCLE TRAUMA AND POSTOPERATIVE STRESS IN HIP FRACTURE PATIENTS: FROM PRECLINICAL MODELS TO CLINICAL PHASE III. T. Winkler, S. Geisler, A. Agres, C. Eder, T. Maleitzke, R. Ofir, P. Reinke, C. Perka, H. D. Volk, G. N. Duda | Scientific Community (Higher Education, Research) | 500 |
| Participation to a conference | P1 - CHARITE (Georg Duda) | Annual Retreat of the BIH Center for Regenerative Therapies (BCRT), Radisson Blu Hotel Berlin, 28 - 29 September 2020 | Talk "Presentation of research fields to the ESC – Musculoskeletal Regeneration" | Scientific Community (Higher Education, Research) | 90 |
| Participation to a conference | P3 - OUH (Hagen Schmal) | HIPGEN – stem cells for sarcopenia treatment – Status of the RCTDen Ortopædkirurgiske Forskningsenhed 26. 02.2018 | Talk | Scientific Community (Higher Education, Research) | 20 |
| Organisation of a workshop | P3 - OUH | Labmeeting 26.02. 2019, Odense | Talk | Scientific Community (Higher Education, Research) | 20 |
| Participation to a conference | P4 - CREM: Ornella Parolini, Andrea Papait (presenting author), Marta Magatti, Elsa Vertua, Antonietta Silini; PLURISTEM: Racheli Ofir | National Conference: Gruppo Italiano Staminali Mesenchimali (GISM, Italian Mesenchymal Stem Cell Group) 2019 Annual Meeting, "Research Challenges for Clinical Applications of MSCs", Genoa, Italy, April 4-5, 2019 | In vitro immunomodulatory comparison of Maternal vs Fetal Placenta-derived cells | Scientific Community (Higher Education, Research) | 150 |
| Participation to a conference | P4 - CREM: Andrea Papait (presenting author), Elsa Vertua, Silvia De Munari, Marta Magatti, Antonietta Silini, Racheli Ofir, Ornella Parolini | 5th International Conference by International Fetal Immunology and Transplantation Society (iFeTIS), Singapore, September 6-7, 2019 | Oral presentation "Comparison of the immunological properties of MSC-like cells from fetal and maternal placenta" | Scientific Community (Higher Education, Research) | 100 |
| Participation to a conference | P4 - CREM: Andrea Papait, Elsa Vertua, Marta Magatti, Antonietta Silini, Racheli Ofir (PLURISTEM), Ornella Parolini (presenting author) | WCO IOF-ESCEO Virtual congress, London (virtual), 26-29 August 2021 - PLURISTEM BREAKFAST SATELLITE SYMPOSIUM - THE HIPGEN TRIAL - CELL THERAPY FOR IMPROVING PATIENT MOBILITY AFTER HIP FRACTURE ARTHROPLASTY | Invited lecture Prof. Ornella Parolini "Fostering tissue regeneration by modulating inflammation: in vitro studies using placenta-derived stem cells to suggest clinical mechanisms of action in immune-related diseases" | Scientific Community (Higher Education, Research) | |
| Organisation of a Conference | P8 - IOF | WCO-IOF-ESCEO, Paris, April 4-7 | Flyer available at IOF booth | Scientific Community (Higher Education, Research) | 4000+ |
| Presentation at a conference | P8 - IOF | October 2019 | Presentation by D Pierroz at the RegMed forun in Berlin | Scientific Community (Higher Education, Research, Physicians) | 100 |
| Organisation of a conference and a workshop | P8 - IOF | August 26-28, 2021 WCO IOF-ESCEO (virtual congress) | Sponsored Satellite Symposium "The HIPGEN trial - CELL therapy for improving patient mobility after hip fracture arthroplasty" | Scientific Community (Higher Education, Research) | 6654 delegates |
| Organisation of a Conference / Participation in a conference | P8 - IOF organisation, P1 - CHARITE (Tobias Winkler), P4 - CREM (Ornella Parolini), P5 - PLURISTEM (Nitsan Halevy), P2 - UOXF (Matthew Costa) participation | World Congress on Osteoporosis-IOF-ESCEO VIRTUAL 2021 26-28th August 2021/Satellite Breakfast Symposium 27th August | Conference organization/HIPGEN presentation | Scientific Community (Higher Education, Research, Physicians) |
HAIFA, Israel, April 25, 2018 - Pluristem Therapeutics Inc
U.S. Food and Drug Administration (FDA) has cleared Pluristem’s Investigational Drug Application (IND) of its PLX-PAD cell therapy for HIPGEN study
HAIFA, Israel, August 08, 2018 - Pluristem Therapeutics Inc
Pluristem Initiates Two Pivotal Phase III Studies in Israel
Indiana, Sptember 23, 2018 - IMRC
IRMC patient receives historic stem cell surgery
Indiana, October 17, 2018 - NewScientist - NEWS & TECHNOLOGY
Human placenta stem cells help people recover from hip surgery
HAIFA, Israel, November 15, 2018 - Pluristem Therapeutics Inc
Pluristem Completes Enrollment of Its Multinational Phase III Study of Muscle Regeneration Following Hip Fracture Surgery
Italy, April, 2019 - PLATINUM
La Placenta, fonte di cellule
Switzerland, August 23, 2021
Learn about the HIPGEN Phase III clinical trial at the Virtual WCO-IOF-ESCEO 2021
• International Osteoporosis Foundation
• EurekAlert
HAIFA, Israel, July 13, 2022 - Pluristem Therapeutics Inc
Pluristem Reports Topline Results from its Phase III Study of Muscle Regeneration Following Hip Fracture Surgery
